Specifications
- Supplier
- Proteintech
- Catalog No
- KE00049
- Sku
- KE00049-96T
- Product Name
- Human P21 ELISA Kit
- Description
- P21 (also known as CIP1, WAF1) is a cyclin-dependent kinase inhibitor. P21 binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at the G1 phase. The expression of P21 is induced by wild-type but not mutant p53 protein, through which P21 mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. P21 can interact with proliferating cell nuclear antigen (PCNA), and plays a regulatory role in S phase DNA replication and DNA damage repair. P21 was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported.
- Size
- 96T
- Image
- https://www.ptglab.com/products/pictures/KE00049-P21.jpg
- Datasheet
- https://www.ptglab.com/Products/Pictures/pdf/Human-P21-ELISA-Kit-KE00049-datasheet.pdf
- Application
- Sandwich ELISA
- Target Immunogen
- P21
- Reactivity
- Human
- Storage
- All the reagents are stored at 2-8℃ for 6 months or -20℃ for 12 months. Refer to the protocol for further storage instructions.
- Shipping
- Blue ice
- Sample Type
- Cell lysates
- Product Type
- ELISAKit
Documentation
No documentation found.
Publications
No publications found.
