Specifications
- Supplier
- MedChemExpress
- Catalog No
- HY-100008
- Product Name
- Peretinoin
- Description
- Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin reduces the mRNA level of sphingosine kinase 1 (SPHK1) in vitro by downregulating a transcription factor, Sp1[1]. Peretinoin prevents the progression of non-alcoholic steatohepatitis (NASH) and the development of hepatocellular carcinoma (HCC) through activating the autophagy pathway by increased Atg16L1 expression[2]. Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with a EC50 of 9 μM[3].
- Size
- 5 mg
- Datasheet
- http://file.medchemexpress.com/batch_PDF/HY-100008/Peretinoin-DataSheet-MedChemExpress.pdf
- Msds
- http://file.medchemexpress.com/batch_PDF/HY-100008/Peretinoin-SDS-MedChemExpress.pdf
- Application
- Cancer-Kinase/protease
- Cas No
- 81485-25-8
- Target Immunogen
- Autophagy;HCV;RAR/RXR;SphK
- Storage
- -20°C (Powder, protect from light, stored under nitrogen)
- Shipping
- Blue Ice
- Product Type
- Reference compound
- Research Area
- Cancer; Infection
- Format
- C20H30O2
- Synonym
- NIK333
Documentation
No documentation found.
Publications
No publications found.
