Specifications
- Supplier
- BT Lab
- Catalog No
- BT-MCA2782
- Product Name
- RFA2 Monoclonal Antibody
- Description
- This gene encodes a subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The RPA complex protects single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which oligonucleotide/oligosaccharide-binding (OB) domains of the complex are utilized, and differing in the length of DNA bound. This subunit contains a single OB domain that participates in high-affinity DNA binding and also contains a winged helix domain at its carboxy terminus, which interacts with many genome maintenance protein. Post-translational modifications of the RPA complex also plays a role in co-ordinating different damage response pathways.
- Size
- 50μL, 100μL
- Application
- WB, IHC, FCM
- Host
- Mouse
- Clone
- 2C5B6
- Clonality
- Monoclonal
- Isotype
- Mouse IgG1,kappa
- Target Immunogen
- RFA2
- Reactivity
- Human
- Storage
- 4°C|-20°C for long term storage
- Format
- Purified antibody in PBS with 0.05% sodium azide
- Synonym
- RP-A p34, RPA2, REPA2, RPA32, RPA34
Documentation
No documentation found.
Publications
No publications found.
