Specifications
- Supplier
- Exalpha
- Product Name
- Mouse anti Human CD61
- Description
- CD61 recognizes an Mr 110-kdalton (kDa) protein, also known as gpIIIa, the common beta-subunit (integrin beta 3-chain) of the gpIIb/IIIa complex and the vitronectin receptor (VNR). The gpIIb/IIIa complex and the VNR are integrins, ie, a/b-heterodimeric glycoprotein complexes that are involved in cell adhesion. With the CD41 antigen (gpIIb or aIIb), the CD61 antigen forms the gpIIb/IIIa complex, which acts as a receptor for fibrinogen, von Willebrand factor (vWf), fibronectin and vitronectin on activated platelets. With the CD51 antigen (VNR a-chain or av), the CD61 antigen forms the VNR, which mediates activation-independent cell adhesion to vitronectin, vWf, fibrinogen, and thrombospondin. The CD61 antigen is found on all normal resting and activated platelets. The CD61 antigen is also found on endothelial cells, megakaryocytes, on some myeloid, erythroid and T-lymphoid leukemic cell lines.
- Size
- 100 µg
- Application
- Flow Cytometry
- Host
- Mouse
- Clone
- 43.PL
- Isotype
- IgG1
- Storage
- Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles
- Shipping
- Ship at ambient temperature
- Product Type
- Primary antibodies
- Purification
- Protein A/G Chromatography
- Concentration
- See vial for concentration
- Source
- Derived from the hybridization of mouse X63.Ag8.653 myeloma cells with spleen cells of BALB/c mice immunized with purified platelet membrane glycoproteins
- Synonym
- CD61
Documentation
No documentation found.
Publications
No publications found.
