0566PRecombinant Mouse anti Human CD56

Specifications

Supplier

Exalpha

Product Name

Recombinant Mouse anti Human CD56

Description

NCAM / CD56, as a member of the immunoglobulin superfamily of adhesion molecules is characterized by several immunoglobulin (Ig)-like domains. The extracellular part of NCAM consists of five of these Ig domains and two fibronectin type III homology regions. NCAM is encoded by a single copy gene composed of 26 exons. However, at least 20-30 distinct isoforms can be generated by alternative splicing and by posttranslational modifications, such as sialylation. During sialylation, polysialic acid (PSA) carbohydrates are attached to the extracellular part of NCAM. Through its extracellular region, NCAM mediates homophilic interactions. In addition, NCAM can also undergo heterophilic interactions by binding extracellular matrix components, such as laminin, or other cell adhesion molecules, such as integrins. NCAM can be found in central and peripheral nerve cells, neuroendocrine tissues and at the surface of NK-cells. Also, NCAM is present in malignancies derived from these tissues and cells.

Application

Flow Cytometry|Immunocytochemistry|Immunohistochemistry (frozen)|Immunohistochemistry (paraffin)

Host

Mouse

Clone

C5.9 E1 (derived from clone C5.9)

Isotype

IgG2b

Storage

The product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

Shipping

The product is shipped at ambient temperature; freeze upon arrival.

Product Type

Primary Antibodies

Purification

Protein A/G Chromatography

Concentration

1 mg/ml

Source

Mouse monoclonal antibody 0566P is a recombinant CD56 monoclonal antibody produced in mammalian HEK293 cells. _x000D_ It is produced by cloning the antibody sequence of the mouse anti CD56 hybridoma C5.9, which was derived from the hybridization of mouse Sp2/0 myeloma cells with spleen cells from BALB/c F1 mice immunized with an extract from the KG1a cell line.

Synonym

CD56/Neural Cell Adhesion Molecule/NCAM