Specifications
- Supplier
- Exalpha
- Product Name
- Mouse anti Human CD56
- Description
- NCAM / CD56, as a member of the immunoglobulin superfamily of adhesion molecules is characterized by several immunoglobulin (Ig)-like domains. The extracellular part of NCAM consists of five of these Ig domains and two fibronectin type III homology regions. NCAM is encoded by a single copy gene composed of 26 exons. However, at least 20-30 distinct isoforms can be generated by alternative splicing and by posttranslational modifications, such as sialylation. During sialylation, polysialic acid (PSA) carbohydrates are attached to the extracellular part of NCAM. Through its extracellular region, NCAM mediates homophilic interactions. In addition, NCAM can also undergo heterophilic interactions by binding extracellular matrix components, such as laminin, or other cell adhesion molecules, such as integrins.
NCAM can be found in central and peripheral nerve cells, neuroendocrine tissues and at the surface of NK-cells. Also, NCAM is present in malignancies derived from these tissues and cells.
- Size
- 25 µg
- Application
- Immunohistochemistry (paraffin)|Flow Cytometry|Immunohistochemistry (frozen)
- Host
- Mouse
- Clone
- C5.9
- Isotype
- IgG2b
- Target Immunogen
- Extract from KG1a cell line.
- Storage
- Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles
- Shipping
- Ship at ambient temperature, freeze upon arrival
- Product Type
- Primary antibodies
- Purification
- Protein A/G Chromatography
- Concentration
- See vial for concentration
- Source
- Derived from the hybridization of mouse Sp2/0 myeloma cells with spleen cells from BALB/c F1 mice immunized with KG1a cell line.
- Synonym
- CD56, NCAM1, Neural Cell Adhesion Molecule
Documentation
No documentation found.
Publications
No publications found.
