0428SMouse anti Human CD4 FITC – CD28 PE

Specifications

Supplier

Exalpha

Product Name

Mouse anti Human CD4 FITC - CD28 PE

Description

Identification of CD4 on human helper/inducer T cells expressing the 60,000 M.W. surface antigen (HLA class II reactive). CD4 is present in low density on monocytes. Anti-human CD28 binds the 44kDa MW cell surface protein on the surface of most T cells. CD28 acts as the ligand for the B7/BB-1 molecule on the surface of activated B cells. B7/BB-1 co-stimulates T cells through CD28, along with CD2 and CD3. CD28 antigen is a disulfide-linked homodimeric glycoprotein. The CD28 antigen is present on approximately 60%-80% of lymphocytes (95% of CD4 and 50% of CD8 lymphocytes). CD28 regulates the expression of cytokines by T cells, not only IL-2, but also IL-1 alpha and CSF-1, usually synthesized by accessory cells. CD28 functions as a cell adhesion molecule (CAM) for certain T cell subsets.

Size

50 Tests

Application

Flow Cytometry

Host

Mouse

Isotype

IgG1 (F)/IgG1 (PE)

Target Immunogen

CD4=Derived from the hybridization of mouse NS-1 myeloma cells with spleen cells from BALB/c mice immunized with human perherial blood T lymphocytes.CD28=Derived from the hybridization of mouse Sp2/O-Ag14 myeloma cells with spleen cells of BALB/c mice immunized with the HPB-ALL T-cell line.

Storage

Product should be stored at 4-8ºC. DO NOT FREEZE

Shipping

Room Temperature

Product Type

Primary antibodies

Purification

Protein A/G Chromatography

Concentration

Titered for flow cytometry

Synonym

CD4 FITC - CD28 PE